A series of "procaine analogs" (I) was prepared by reaction of dialkylaminoalkoxyphenylethanols with aromatic acid chlorides. Upon evaluation as anesthetics, selected compounds showed considerably more activity than procaine.N THE "PROCAINE" type of local anesthetics (l), I lengthening of the alkylene chain separating the tertiary amino group and the ester group increases anesthetic activity as well as toxicity. These conclusions are substantiated in the recent work from other laboratories (3,3). Extension of our explorations (4) to compounds of type I was indicated in the hope of increasing anesthetic potency with no accompanying increase in toxicity.
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