Several Multi-Criteria-Decision-Making methodologies assume the existence of weights associated with the different criteria, reflecting their relative importance.One of the most popular ways to infer such weights is the Analytic Hierarchy Process, which constructs first a matrix of pairwise comparisons, from which weights are derived following one out of many existing procedures, such as the eigenvector method or the least (logarithmic) squares. Since different procedures yield different results (weights) we pose the problem of describing the set of weights obtained by "sensible" methods: those which are efficient for the (vector-) optimization problem of simultaneous minimization of discrepancies.A characterization of the set of efficient solutions is given, which enables us to assert that the least-logarithmic-squares solution is always efficient, whereas the (widely used) eigenvector solution is not, in some cases, efficient, thus its use in practice may be questionable.

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The development of calcitonin cells (C-cells) was investigated in rat thyroid glands from birth to 120 days, using an immunoperoxidase technique and a point-counting method. The proportion of C-cells to follicular cells was 4.5% on the day of birth and increased progressively to 10.4% by 120 days. The highest density of C-cells was noted in the mid-region of the lobes along a longitudinal axis. The caudal and cephalic regions of the lobes contained smaller numbers of C-cells. The C-cells tended to be more numerous in the posterior aspects of the lobes. Although the numbers of C-cells in 120-day-old animal were markedly increased as compared to animals at the time of birth, the cell distributions within the glands were similar at all ages.

Sequential testing with brief cognitive tools has been recommended to improve cognitive screening and monitoring, however the few available tools still depend on an external evaluator and periodic visits. We developed a self-administered computerized test intended for longitudinal cognitive testing (Brain on Track). The test can be performed from a home computer and is composed of several subtests, expected to evaluate different cognitive domains, all including random elements to minimize learning effects. An initial (A) and a refined version of the test (B) were applied to patients with mild cognitive impairment or early dementia (n = 88) and age and education-matched controls. A subsample of a population-based cohort (n = 113) performed the test at home every three months to evaluate test-retest reliability. The test’s final version Cronbach’s alpha was 0.90, test scores were significantly different between patients and controls (p = 0.001), the area under the receiver operating characteristic curve was 0.75 and the smallest real difference (43.04) was lower than the clinical relevant difference (56.82). In the test-retest reliability analysis 9/10 subtests showed two-way mixed single intraclass consistency correlation coefficient >0.70. These results imply good internal consistency, discriminative ability and reliability when performed at home, encouraging further longitudinal clinical and population-based studies.

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In this paper we address the problem of ranking a set of alternatives with partial information about the weighting coefficients. We introduce a family of quasiorders that are easily interpretable and manageable, which includes among others, the natural quasiorder in R n and other well known preference structures in the literature. The enrichment of the preference structure with respect to the natural quasiorder is measured by means of an absolute measure we introduce.

In this paper we consider a loss system where the arrivals can be classified into different groups according to their arrival rate and expected service time. While the standard admission policy consists of rejecting only those customers who arrive when all servers are busy, we address the problem of finding the optimal static admission policy (with respect to a given reward structure) when customers can be discriminated according to the group they belong to, thus customers of some groups might be automatically rejected (even if some servers remain idle) in order to enhance the global efficiency of the system. The optimality of a c\mu -rule is shown, from which finite-time algorithms for the one- and two-server cases are derived.Algorithms, Multichannel Queues, Nonlinear Programming, Optimization

C cells are primarily known for producing calcitonin, a hypocalcemic and hypophosphatemic hormone. Nevertheless, besides their role in calcium homeostasis, C cells may be involved in the intrathyroidal regulation of follicular cells, suggesting a possible interrelationship between the two endocrine populations. If this premise is true, massive changes induced by different agents in the activity of follicular cells may also affect calcitonin-producing cells. To investigate the behaviour of C cells in those circumstances, we have experimentally induced two opposite functional thyroid states. We hyperstimulated the follicular cells using a goitrogen (propylthiouracil), and we suppressed thyroid hormone synthesis by oral administration of thyroxine. In both scenarios, we measured T 4 , TSH, calcitonin, and calcium serum levels. We also completely sectioned the thyroid gland, specifically immunostained the C cells, and rigorously quantified this endocrine population. In hypothyroid rats, not only follicular cells but also C cells displayed hyperplastic and hypertrophic changes as well as increased calcitonin levels. When exogenous thyroxine was administered to the rats, the opposite effect was noted as a decrease in the number and size of C cells, as well as decreased calcitonin levels. Additionally, we noted that the two cell types maintain the same numerical relation (10 ± 2.5 follicular cells per C cell), independent of the functional activity of the thyroid gland. Considering that TSH serum levels are increased in hypothyroid rats and decreased in thyroxine-treated rats, we discuss the potential involvement of thyrotropin in the observed results.