This paper adopted in silico and bioinformatics scientific approaches in revealing the nature of the COVID-19 coronavirus strain in Nigeria. These was revealed in terms of the physical, chemical and biological nature, as well as the isoelectric point, evolutionary relationship, mutation rate and pathway, molecular weight amongst other attributes which project the coronaviruses mutant strains causing the current global pandemic as very deadly and a threat to humanity. The paper revealed the genetic and thermal stability status of the Nigerian (COVID-19) isolate using instability index, aliphatic index, guanine – cytosine content, hydropathicity, nucleotide diversity, amino acids side chains and half-life of the isolate on in vitro human reticulocyte cells as criteria. The paper also revealed the variations in protein structures, phylogeny, bad angles, bad bonds, C-Beta deviations, Ramachandran outliers and Molprobity scores of the virus pathogen in Nigeria and that of Wuhan China, the global epicenter of the pandemic and deduced strong relationship between the strains confirming their common ancestry and nature. The paper revealed that efforts geared towards the development of suitable therapy and vaccines for the COVID-19 globally has not yet been successful due to the variable attenuation coefficients and the fast rate of the S gene mutations of the coronaviruses mutant strains. Hence, the nature of COVID-19 revealed in this study, is necessary for the identification, design and development of effective treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.