BY 1D AND 2D NMR. The synthesis and NMR analysis of seven new 4-(aryl)amino-5-carboethoxy-1,3-dimethyl-1H-pyrazolo[3,4b]pyridines (7-13) are described. The synthetic approach used involved the preparation of intermediates 5-aminopyrazol (4), the enamine derivative (5) and the 4-chloro-1H-pyrazolo[3,4b]pyridine (6). Compounds (7-13) were obtained by treatment of 6 with the desired aniline. The structures of new heterocyclic compounds and their precursors intermediates were assigned on the basis of spectral analysis including 1D and 2D NMR experiments [ 1 H; 13 C{ 1 H} and DEPT; 1 H x 1 H-COSY; 1 H x 13 C-COSY, n J CH , n = 1, 2 or 3 (HETECOR and COLOC)].
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