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Thirty‐two patients with metastatic carcinomas were treated with mitomycin C. Three of them developed renal toxicity within 6 to 7 months of therapy. The toxic effect was mainly on the glomerular tuft and especially on the nuclei. Nephrotoxicity of mitomycin C has been noticed in rhesus monkeys, but has never been reported in man. Patients who are being treated with mitomycin C should be observed for a rising blood urea nitrogen, serum creatinine, and albuminuria.

of the light chromidia (microsomes), which were spun down after two hours at 18,000 x g with Servall SS-1 centrifuge from samples diluted with sufficient water to make the sucrose isotonic. If the initial centrifugal force was below 600 x g, a heavy contamination