No abstract

BackgroundAtopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that a ects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse e ects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs). ObjectivesTo assess the e icacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments. Search methodsWe searched the following databases up to 3

Cisplatin versus carboplatin in combination with third-generation drugs for advanced non-small cell lung cancer.

BackgroundIncontinence a er prostatectomy for benign or malignant disease is a well-known and o en a feared outcome. Although small degrees of incidental incontinence may go virtually unnoticed, larger degrees of incontinence can have a major impact on a man's quality of life.Conceptually, post-prostatectomy incontinence may be caused by sphincter malfunction or bladder dysfunction, or both. Most men with post-prostatectomy incontinence (60% to 100%) have stress urinary incontinence, which is involuntary urinary leakage on e ort or exertion, or on sneezing or coughing. This may be due to intrinsic sphincter deficiency and may be treated with surgery for optimal management of incontinence. Detrusor dysfunction is more common a er surgery for benign prostatic disease. ObjectivesTo determine the e ects of surgical treatment for urinary incontinence related to presumed sphincter deficiency a er prostate surgery for:-men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) -transurethral resection of prostate (TURP), photo vaporisation of the prostate, laser enucleation of the prostate or open prostatectomy -and -men with prostate cancer -radical prostatectomy (retropubic, perineal, laparoscopic, or robotic). Search methodsWe searched the Cochrane Incontinence Group Specialised Register, which contains trials identified from Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE in process, ClinicalTrials.gov, and handsearching of journals and conference proceedings (searched

No eligible trials were identified that compared alternative routes of catheter insertion. The data from eight trials comparing different antibiotic policies were sparse, particularly when intermittent catheterisation was considered separately from indwelling catheterisation. Possible benefits of antibiotic prophylaxis must be balanced against possible adverse effects, such as development of antibiotic resistant bacteria. These cannot be reliably estimated from currently available trials.