Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

Retrobulbar chlorpromazine appears to be safe and effective for the management of pain in blind eyes.

An interventional case report is described of a patient with chronic postoperative endophthalmitis caused by the gram-negative aerobic rod Pseudomonas luteola. A 61-year-old developed slowly progressive blurring of vision, hypopyon, and vitritis following cataract surgery. Diagnostic vitrectomy and intraocular lens explantation were performed. The undiluted vitreous samples and explanted lens were analyzed. Aerobic cultures revealed moderate growth of P. luteola. The patient responded to intravitreal injections of piperacillin/tazobactam and oral trimethoprim/sulfamethoxasole. Best-corrected visual acuity improved from hand motions to 20/40. A repeat anterior chamber tap was negative. P. luteola may be a relatively nonvirulent cause of chronic endophthalmitis. Good visual outcomes may be obtained with appropriate therapy.

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