Research has shown that the principal cause of cetuximab-induced anaphylaxis is antioligosaccharide IgE antibodies specific for galactose-a-1,3-galactose (a-Gal) present on the mouse-derived Fab portion of the cetuximab heavy chain. Furthermore, it has been revealed that patients who are allergic to cetuximab also develop an allergic reaction to mammalian meat containing the a-Gal owing to cross-reactivity, and the presumed cause of sensitization
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