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re more people doing wrong or are more people speaking up? Retractions of scientific papers have increased about tenfold during the past decade, with many studies crumbling in cases of high-profile research misconduct that ranges from plagiarism to image manipulation to outright data fabrication. When worries about somebody's work reach a critical point, it falls to a peer, supervisor, junior partner or uninvolved bystander to decide whether to keep mum or step up and blow the whistle. Doing the latter comes at significant risk, and the path is rarely simple. Some make their case and move on; others never give up. And in what seems to be a growing trend, anonymous watchdogs are airing their concerns through e-mail and public forums. Here, Nature profiles three markedly different stories of individuals who acted on their suspicions. Successful or otherwise, each case offers lessons for would-be tipsters. WAYS TO BLOW THE WHISTLE Reporting suspicions of scientific fraud is rarely easy, but some paths are more effective than others.

In the process of mining activity, many kinds of heavy metals enter into soils with dust, causing serious contamination to the environment. In this study, six soils were sampled from cropland at different distances from a lead/zinc mine in Heilongjiang Province, China. The total contents of lead and zinc in the vicinal cropland exceeded the third level of environmental quality standard for soil in China, which indicated that soils in this area were moderately contaminated. Bacterial community diversity and population were greatly decreased when the concentrations of lead and zinc were beyond 1,500 and 995 mg kg(-1), respectively, as analyzed by plate counting and polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE). The bands of DGGE patterns varied with the degree of contamination. The activities of soil urease, phosphatase, and dehydrogenase were negatively correlated with the concentrations of lead and zinc. The highest inhibitory effect of heavy metals on soil enzyme activities was observed in urease. It was noted that PCR-DGGE patterns combined with soil enzyme activity analysis can be indices for the soil quality assessment by heavy metal contamination.

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