Iridoid glycosides are 2-cyclopentanoid derivatives of terpene origin naturally occuring in the leaves, fruits, seeds, bark, roots of various plants. They are medically important because used in the treatment of many diseases while normally protect plants from biotic and abiotic attacks. They have anti-microbial, anti-tumor, anti-cardiac and anti-inflammatory effects. Ipolamiide is one of the iridoid glycosides and naturally present in many plants. Ipolamiide is very little known compound in terms of the biological activities. The beneficial microorganisms in the body and the plant secondary metabolites can interact in the human gastrointestinal tract. Probiotics are live microorganisms that have many health benefits by improving microbial balance of the intestines. Among the most known and most studied probiotics are Lactobacillus acidophilus and Lactobacillus rhamnosus. The aim of the present study is to investigate the effects of ipolamiide on probiotic bacteria Lactobacillus rhamnosus GG (GG) and Lactobacillus acidophilus LA-5 (LA-5). For this purpose, ipolamiide was added to the growth of probiotics in different concentrations and its effects on bacterial growth kinetics, bacterial surface hydrophobicity (Microbial Adhesion to Solvents-MATS Test) and bacterial aggregation (Auto-Aggregation Test) were investigated. The results showed that ipolamiide did not show any important change in surface hydrophobicity of probiotic bacteria. Dose-dependent increases in auto-aggregation properties of the LA-5 and GG were observed. However, further detailed studies are required to give insight into other possible biological activities of ipolamiide.
İnsanların doğal ve besleyici gıdalara olan ilgisi son yıllarda iyice artırmıştır. Günümüzde meyve ve sebzeler sadece beslenme amacının dışında hastalıklardan korunmak, sağlıklı yaşamak, ve tedavi edici özellikleri de göz önüne alınarak tüketilmektedir. Bu nedenle meyve ve sebzeler, içerikleri bakımından da tercih edilmektedir. Domatesten (Solanum lycopersicum) adını alan likopen, başta domates olmak üzere çeşitli bitkilerde bulunan kırmızı renkli karotenoid bir pigmenttir. Likopen in vitro ortamlarda güçlü bir antioksidan özellik gösterir, in vivo ortamlarda ise DNA, protein ve lipitlerin oksidasyonuna karşı koruyucu olmasının yanı sıra kanser tedavisinde apoptozu indüklemek, DNA hasarını azaltmak, oksidatif stresi önlemek, metastazı azaltmak ve kanser hücre siklusunu bozmak gibi çok hedefli aktiviteleri de bulunmaktadır. Lactobacillus acidophilus ve Lacticaseibacillus rhamnosus, probiyotikler arasında çok çalışılan, popüler mikroorganizmalar arasındadır. Özellikle sindirim sisteminde, Lactobacillus acidophilus ve Lacticaseibacillus rhamnosus gibi probiyotik bakterilerin varlığı, bağırsak florasını olumlu yönde etkileyerek sindirimi kolaylaştırabilir ve bağışıklık sisteminin güçlenmesine yardımcı olabilir. Bu probiyotiklerin yararlı etkileri, bitkisel kaynaklı bileşiklerle ve vücudumuzdaki faydalı mikroorganizmalarla etkileşimleri sayesinde artabilir. Bu çalışma ile insan diyetinde yer alan meyve ve sebzelerde doğal olarak bulunan ve birçok yararlı etkisiyle birlikte likopenin insan sağlığı için önemli olan probiyotik bakteriler Lacticaseibacillus rhamnosus ve Lactobacillus acidophilus üzerine etkileri araştırılmıştır. Çalışma sonuçları, likopenin probiyotik bakterilerin yüzey hidrofobisitesinde ve mukus adezyon testinde önemli bir değişikliğe sebep olmadığını, otoagregasyon özellikleri üzerinde doza bağlı artışların olduğunu göstermiştir.
Schiff bases have been widely researched in vitro for their antimicrobial, antitumor, antiviral, antineoplastic, and antioxidant properties, owing to their strong chelating ability. Probiotics refer to “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. The goal of this research was to explore the abilities antibacterial, anticancer, and antioxidant effects of Schiff Bases N-methylene-N-phenylbenzenaminium and N-(5-oxopentylidene)-N-phenylbenzenaminium, as well as their impact regarding the properties of probiotics of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. The results indicate that these Schiff bases promote the growth of probiotic bacteria while inhibiting pathogenic bacteria. They demonstrate potent antibacterial and antioxidant activities, and cytotoxicity assays reveal that both compounds exert a high degree of inhibition on the human colon (HT-29 and Caco-2) and breast (MCF-7) cancer cells. Additionally, there is a notable rise or substantial growth in auto-aggregation and surface hydrophobicity of probiotic bacteria. In conclusion, the Schiff bases investigated in this study possess significant therapeutic potential.
Industrialization and the increase in the world population increase the need for energy.Supercapacitors are preferred because of their features such as high specific power, long life, environmentalfriendliness, fast charge, and discharge rates. Supercapacitors are divided into two categories as EDLC andpseudo capacitors. Pseudo capacitors use materials that exhibit pseudo capacitance, such as transition metaloxides/sulphides and conductive polymers. Electrochemical studies and synthesis methods of polymerbased metal oxide composites, polyaniline and polypyrrole are examined in detail. Evaluating the variousmethods used in the preparation of supercapacitor electrodes, an idea is presented on the selection ofsuitable materials for electrochemical applications. Conductive polymers have good capacitance behaviorbut low cyclic stability. Transition metal sulfides exhibit electrochemical performance with highcapacitance values and excellent redox reversibility. This study investigates NiS/PPy polymer assupercapacitor electrode material. The NiS structure was synthesized using Na2S and nickel foam. NiS-PPycoating was carried out by electrochemical coating method. Structures were characterized by XRD andSEM, electrochemical studies such as cyclic voltammetry (CV), galvanostatic discharge (GCD) werecarried out. By incorporating NiS into the PPy matrix, the C value was increased from 22.22 to 1404 F g-1
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.