Aim: To study the effects of orally administered mixture of Hippophae rhamnoides leaf and marc extracts (HLM) on health parameters of newborn calves. Study Design: Starting from birth day 0 (D0) till day 15 (D15) the extract of HLM was given orally to newborn calves before feeding them milk at an increased dosage from 5 to 8 ml/calf/ two times a day for prophylaxis of nutritional diarrhoea. The calves were clinically examined and weighed. Biochemical and morphological analyses of blood were determined.