THE AIM: This study aimed to evaluate the effects of xenon on neuropathic pain during parapulmonal injections in the rat model. Xenon is a drug for inhalation anesthesia that is assumed to have an analgesic effect when administered parapulmonary (similar to nitrous oxide and cyclopropane) and can later be used as an alternative analgesic drug in patients with pain syndrome that is not controlled by standard methods. MATERIALS AND METHODS: The experiment used in vivo model of neuropathic pain by Bennet and Xie (1988) on rats with sciatic nerve transection. Additionally, a special scoring was adopted based on known behavioral changes of experimental animals (self-harm of limbs, neatness, activity, and bedding conditions). The control group was subcutaneously administered air daily for 5 days, and the experimental group received medical xenon at 40 ml/kg. The pain was assessed with the subcutaneous introduction of air and xenon in the experimental and control groups. RESULTS: Study results revealed that rats from the experimental group (xenon) showed fewer signs of neuropathic pain syndrome development compared to the control group (air). CONCLUSION: Therefore, parapulmonal injections of xenon showed a high analgesia effect in animal models of chronic neuropathic pain.
As a result of population aging and increasing of comorbide patients procent, chronic pain nowadays is the one of the most important medical problems and its treatment becoming one of progressive and popular researching topics. First part of acute or chronic pain research is a model that meets the specified criteria. First model of cronic pain sciatic nerve damaging was founded and proven more than 30 years ago. Nowadays there is a lot of in vivo and in vitro models that matched with different pathologies and also mechanisms of chronic nociceptive and neuropathic pain on different levels have been learned. In this article we review the most effective and often used rat models of chronic pain its mechanisms and assessment methods. The information based on the most citated articles for 10 years.
Pain syndrome is the most common reason for patients to seek medical care, the importance of which is steadily increasing in the structure of the total incidence. To optimize costs and ensure high-quality treatment of patients with chronic pain syndrome it is necessary to study existing drugs and methods and introduce new ones. Based on theoretical data on the use of inert gases in medicine, a hypothesis was put forward that xenon could have a pronounced analgesic effect when administered subcutaneously. This study is aimed at confirming the safety of xenon in parapulmonary administration to rats.
This article is about I Russian scientific and practical conference with the international participation Actual questions of chronic pain management held on May 13-14 in Krasnoyarsk. The conference was organized by the Federal State Budgetary Institution of Healthcare of the Federal Scientific and Practical Center of the Federal Medical and Biological Agency of Russia, the KrasSMU, and the Association of Interventional Pain Treatment. Speakers from nine cities discussed wide and narrow questions of interventional and cancer pain treatment and other pain management directions. Additionally, two regional anesthesia under ultrasound control master classes were conducted. Approximately 360 people participated in the conference, both online and offline.
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