The Bohm-de Broglie interpretation of quantum mechanics is applied to canonical quantum cosmology. It is shown that, irrespective of any regularization or choice of factor ordering of the Wheeler-DeWitt equation, the unique relevant quantum effect which does not break spacetime is the change of its signature from lorentzian to euclidean.

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The causal interpretation of quantum mechanics is applied to a homogeneous and isotropic quantum universe, whose matter content is composed by non interacting dust and radiation. For wave functions which are eigenstates of the total dust mass operator, we find some bouncing quantum universes which reachs the classical limit for scale factors much larger than its minimum size. However these wave functions do not have unitary evolution. For wave functions which are not eigenstates of the dust total mass operator but do have unitary evolution, we show that, for flat spatial sections, matter can be created as a quantum effect in such a way that the universe can undergo a transition from an exotic matter dominated era to a matter dominated one.