Zusammenfassung Der antimikrobiell wirksame Propolisinhaltsstoff Pinocembrin (5,7‐Dihydroxyflava‐non) wurde am Modell der experimentellen Candida‐Infektion der Maus auf seine in two‐Effektivität untersucht. Hierzu eignete sich die intravenöse Infektion hauseigener Mäuse eines AB‐Jena‐Stam‐mes mit 2,5 × 105 Candida albicans‐ZeWen besonders gut. Bei täglicher peroraler Applikation von 100mg/kg Pinocembrin starben die Tiere wie die Kontrollmäuse zwischen dem 6. und 24. Versuchstag. Alle Tiere, die 5 mg/kg Amphotericin B intravenös erhielten, überlebten die 30tägige Beobachtungszeit. Die Frage nach der Unwirksamkeit des Pinocembrins in vivo sollte in pharmakokinetischen Untersuchungen abgeklärt werden. Summary Pinocembrin (5,7‐dihydroxy‐flavanon) – a component of the bee product propolis – was tested for its in vivo activity against Candida albicans in mice. It was shown that the intravenous infection of AB‐Jena mice with 2.5 × 105 Candida albicans cells was a very suitable model. Despite of treatment with pinocembrin at daily doses of 100 mg/kg body weight the animals as well as the controls died between the 6th and 24th day after beginning. On the other hand the animals treated with 5 mg/kg amphotericin B survived the test‐period of 30 days. The question of ineffectiveness of pinocembrin in vivo should be cleared up in further pharmacokinetic investigations.
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