Summary Glomerular filtration rate (GFR), '3'I-Hippuran clearance and estimated creatinine clearance were investigated in 34 patients with cancer. For Hippuran clearance and GFR, analysed with the X-ray contrast (iohexol) and fluorescence technique, the least square linear regression coefficient was 5.01 ± 0.41 (r = 0.91). This value concurs with the five to one ratio between GFR and renal plasma flow known from normal physiology and supports that Hippuran clearance is a valid measure of renal function. When the individual values of Hippuran clearance were divided by 5.01, the mean difference between the methods was 0.4 ml min' 1.73 m2 with standard deviation 13.4 ml min-' 1.73 m2. The lower and upper limits of agreement were -26.7 and 25.9 ml min-' 1.73 m2, respectively. Comparing creatinine clearance estimated from the serum creatinine level with GFR, the limits of agreement were -29.4 and 21.6 ml min-' 1.73 m-2. These agreement limits are in the same range as those which can be calculated from the data from other studies.
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