Background:The CD2AP adaptor facilitates cell signaling using its in-built interaction modules (SH3 domains). Results: RIN3 was characterized as a novel CD2AP SH3 binding protein by biophysical and biochemical methods. Conclusion: CD2AP has many potential interactors and is probably a cellular hub. Significance: We reveal how protein modules can interact with families of related recognition motifs rather than a single motif.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.