A novel quantitative liver function test is described which is based on monoethylglycinexylidide (MEGX) formation after lidocaine bolus injection. Following the administration of small single doses of lidocaine hydrochloride (l mg/kg), monoethylglycinexylidide serum concentration-time curves were determined by a novel highly sensitive fluorescence Polarisation immunoassay (FPIA) in healthy volunteers, liver donors and patients with liver cirrhosis. The FPIA allowed rapid and reliable monoethylglycinexylidide determinations in serum and urine (between-days coefficient of Variation: < 10.3%, recovery: 80-113%). Monoethylglyci-1 Preliminary results of this study were presented at the Third Meeting of the German Association för the Study of the Liver in

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