It was found that under conditions of hyperthermia, morphofunctional changes develop in the interrenal part of the adrenal glands, indicating an increase in the functional activity of the gland. The study of ducks on the 5th day of hyperthermia revealed loosening and thickening of the adrenal gland capsule compared to the control. Significant hemodynamic disorders were noted: the phenomena of stasis and erythrocyte sludge in sharply expanded blood capillaries of the adrenal glands. It was found that on the 10th day of hyperthermia, hemodynamic disorders are progressive: the phenomena of sludge and red blood cell stasis are less pronounced, but parenchymal edema and a sharp expansion of sinusoid capillaries persist. Changes in interrenal cells (their high prismatic shape, cytoplasmic vacuolization, apical granularity) are also determined to characterize the high secretory activity of endocrinocytes. The found changes indicate the development of a stress reaction.
The state of the protein, carbohydrate-lipid and mineral metabolism, as well as the functional state of parenchymal organs using the drug Introvit-EC-100 Oral and ascorbic acid to correct hyperthermia in ducks are under the study. It was established that in all the studied groups there was a high content of total protein, due to dehydration and loss of the liquid component of the blood during hyperthermia. Ducks of the experimental groups showed a significant decrease in total protein level, β-globulins, an increase of albumin, a stable level of α- and γ-globulins was more pronounced in the first group. In ducks of the control group, no significant changes in the level of total protein and fractions, with the exception of α- and β-globulins, were found. During the experiment, there was a tendency of reduction of the creatinine content in the blood serum of ducks of both experimental groups, against the background of a consistently high level in ducks of the control group. Thus, the drug Introvit-EC-100 Oral, when used daily for 30 days at a prophylactic dose, has a significant effect on restoring the level of total serum protein, uric acid, creatinine, and the protein fraction ratio.
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