. (1977). Thorax, 32,[444][445][446][447][448] There is a paucity of published information regarding the incidence of sternal metastases. Even less is known about the incidence of pathological fractures (meaning, in this study, fractures secondary to metastatic tumour). The reasons for this gap in our knowledge are twofold: first, metastatic tumours and pathological fractures of the sternum are rare (Gompels et al., 1972) and there has been an insufficient amount of histological material available to enable conclusions about the incidence to be reached; secondly, a reliable and rapid method of determining the presence of these lesions has not been widely used. It is our purpose in this communication to report the incidence of metastases and of pathological fractures of the sternum derived from a large necropsy series of a cancer institute (Princess Margaret Hospital) and a general hospital (Wellesley Hospital), to characterise the pathological fractures according to site and deformity, and to outline a quick and reliable technique for determining the presence of these lesions.
The biological behaviour and histopathology of an experimental osteosarcoma in rats are described as a model to study the human disease. The tumour was developed by injection of Moloney murine sarcoma virus into the tibial marrow space of three strains of inbred new-born rats. The resulting neoplasm was highly malignant and arose after a short latent period of only 10 days. It was readily maintained in tissue culture and was transplantable to adult rats. The virus induced tumour resembled human osteosarcoma in pattern of growth, tumour osteoid production, reaction of adjacent bony tissues and distribution of metastases, being an excellent model for the study of the interaction between oncogenic viruses and skeletal tissues. The analogies and differences between this and other virus-induced murine tumours and human osteosarcoma are discussed.
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