No abstract

The role of cyclodextrins in the bioproduction of resveratrol in the presence of methyl-jasmonate is rationalized, leading to solutions for the improvement of bioproduction.

Fig. 1. Linear map of the plasmids. (a) Schematic representation of the genetic structures surrounding bla NDM-5 gene and (b) structure of bla CMY-42 genetic environment. Letter to the Editor / Clinical Microbiology and Infection 23 (2017) 489e490

Bearing grafts based on fatty esters derivatives, lipidyl-cyclodextrins (L-CDs) are compounds able to form water-soluble nano-objects. In this context, bicatenary biobased lipidic-cyclodextrins of low DS were easily synthesized from a fatty ester epoxide by means of alternative methods (ball-milling conditions, use of enzymes). The ring opening reaction of methyl oleate epoxide needs ball-milling and is highly specific of cyclodextrins in solventless conditions. L-CDs are thus composed of complex mixtures that were deciphered by an extensive structural analysis using mainly mass spectrometry and NMR spectroscopy. In addition, as part of their potential use as vectors of active drugs, these products were submitted to an integrity study on in vitro model of the blood-brain-barrier (BBB) and the intestinal epithelium. No toxicity has been observed, suggesting that applications for the vectorization of active ingredients can be expected.