Prostaglandin (PG) El was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL3) to low density lipoproteins (LDL). The enhancement effect of PGE~ on the interlipoprotein lipid transfer was seen at low PG concentrations under conditions of spontaneous exchange as well as in the presence of lipoprotein-depleted plasma, or partly purified plasma lipid exchange protein. PGE2 and PGF2~ showed no significant influence on the interlipoprotein lipid transfer. Evidence is presented suggesting that the PGEl-induced stimulation of interlipoprotein lipid exchange results in enhancement of LCAT-catalyzed cholesterol esterification in plasma. It is proposed that the effect of PGEj is due to the previously described PGEi-induced reorganization of the HDL surface [(1984) FEBS Lett. 173,291-293] and that PG-lipoprotein interaction may be a factor regulating cholesterol homeostasis.
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