In four groups of persons, l/healthy individuals, 2/ patients with diabetes mellitus, 3/ patients with peripheral vascular disease, and 4/ patients with hyperthyroidism, the urinary excretion of frce cortisol, cortisone, cortisol sulfate and cortisone sulfate was estimated. In groups 2 and 3 the excretion of all four substances was elevated. In hyperthyroidism a preponderance of free cortisone over cortisol was registered. The ratias of the followed substances suggest in patients with peripheral vascular disease a detoriation in the normal excretion of the followed corticoids, based on a preponderance of ll-OH-corticosteroids over their II-oxo-denvatives. This observation could be implicated in the mild hyperglycemia or decreased glucose tolerance, tha t is often found in atherosclerotic disease.
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