A brief historical review of the investigations of the reaction mechanism and kinetics in the reactions of isonitriles with heme iron in hemoglobins, myoglobins, and cytochromes is given.It is shown how from the hypothesis of Pauling with the throughgoing investigations by others a real "pocket" model to describe the forming of the binding of ligands with ferro-heme was reached.An abstract of toxicity of isonitriles is also given.
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