A 52-year-old woman was admitted because of epigastralgia, anorexia and recently increased vomiting, 2 years after silastic ring vertical gastroplasty. On gastroscopy, a tumor mass was visualized in the pouch near the "neo-pylorus". Biopsies confirmed adenocarcinoma. She underwent total gastrectomy, and has no evidence of recurrence at 1 year. The literature on gastric carcinoma after gastroplasty is reviewed.
Deletion of the 13q14 chromosomal region is frequent in B cell chronic lymphocytic leukemia (B-CLL) and is believed to inactivate a tumor supressor gene (TSG) next to RB1. We studied microsatellite markers spanning the 13q14 chromosomal region in 138 children with acute lymphoblastic leukemia (ALL). Allelic loss was demonstrated in six cases (4.3%). Deletion did not include RB1 in two cases. In five patients, the deleted region overlapped that described in B-CLL. A sixth patient harbored a smaller deletion, slightly more telomeric than minimal deleted regions reported in B-CLL. Apparent differences in the delineation of the minimal deleted region could be due to the fact that the putative TSG is a very large gene, with some deletions affecting only a part of it. Our present findings suggest that at least some of its exons lie within a region of less than 100 kb more telomeric that previously thought. Leukemia (2001) 15, 371-376.
Lymphorrhea is a rare but potentially serious complication following various surgical procedures. Uncontrolled lymph drainage may lead to infection and prolonged hospital stay. Currently, there is no standard effective treatment. Early management usually involves bed rest, drainage and pressure dressings. These methods are associated with prolonged recovery and high recurrence rates. We report a case of lymphorrhea from the groin wound after an aortic valve replacement. The patient presented with significant lymph drainage from the postoperative inguinal wound. Lymphorrhea was successfully treated with a long-acting somatostatin analogue, lanreotide. No recurrence was observed after 1 and 6 months of patient follow-up. This case report demonstrates the successful use of lanreotide in the control of lymphorrhea following groin dissection for vascular access.
A quantitative measure of distance between dialects known as dialectometry may be applied to dialect studies. Agglomerative hierarchical classification analysis, as developed by Dennis Philps (1985), is one possibility which the dialectometric procedure makes available for the analysis of multivariate data.The purpose of agglomerative hierarchical classification analysis is to obtain an areal structure of the linguistic data under study. This analysis is a synthesis of the variables of a number of linguistic items instead of just one. Mathematically processed classes of linguistic variables, when mapped, resolve into geolinguistically coherent dialect areas, which in turn bring into focus linguistic boundaries. Agglomerative hierarchical classification analysis is particularly conducive to studies of linguistic groups having a history of population movement because the spatial patterns that can be identified open up possibilities for the interpretation of regional contrasts and linguistic boundaries as well as linguistic change.Our analyst, Eric Lebrun, adapted Philp's agglomerative hierarchical analysis so that it could be used to analyze the lobster-fishing terminology of Acadian fishermen living on the two islands of Miscou and Lameque in northeast New Brunswick. At this stage of our research, the dendrogram and mapped-cluster representations of the areal structure were drawn manually. The patterns which revealed themselves using this analysis provided us with both a synchronic and a diachronic explanatory framework for our data. The results of our research were published in Babitch 1988. A Canada Social Sciences and Humanities Research Council grant (1988) for the Atlas linguistique des provinces Atlantiques project is permitting us to computerize the hierarchy-of-clusters graphic representations and to continue research into the possibilities offered by a dialectometric analysis of the maritime terminology of Acadian fishermen living in the provinces of Nova Scotia, Prince Edward Island, and New Brunswick.
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