MC «Eugenia», Blagoveschensk, RussiaFar Eastern scientific center of physiology and pathology of respiration North-western state medical university named after I. I. Mechnikov, Saint-Petersburg, Rus-sia Abstracts: It is well known that bronchial asthma (BA) is in the leading place in the structure of morbidity of respiratory organs is the most important problem of modern pulmonology.As you know, the nature of the clinical course and severity of BA largely depends on the ac-tivity of the inflammatory process that begins with damage to the bronchial epithelium, disorders of microcirculation and the subsequent interaction of key effector cells and their mediators.BA is accompanied by a systemic response of the organism to inflammation in the lung tis-sue and involved in this type of mediators, including Pro -and anti-inflammatory cytokines, chemokines, leukotrienes, prostaglandins and others, determine the mechanisms of disease develop-ment.In the literature available to us there is a lot of information, details and evidence character-izing the role of cytokines in the development and course of BA. However, these studies presented a lot of data, but they are, in our opinion, do not allow to present a clear picture of the changes of the cytokine profile in asthma, depending on the shape and severity of the disease. In addition, there are difficulties in the interpretation of cytokine regulation in asthma because the pathogene-sis of this disease are «working» complex allergic and non-allergic mechanisms.In this regard, exploring the use of a set of biomarkers of inflammatory activity, in particular of Pro -and antiinflammatory cytokines for evaluation of the prognosis of BA is of great practical importance.Bronchial asthma (BA) is accompanied by a systemic response of the organism to the in-flammation in lung tissue and involved in this type of mediators, including pro -and anti-inflammatory cytokines, chemokines, leukotrienes, prostaglandins and others, determine the mechanisms of disease development.
Background. Is to investigate clinical and pathogenetic features of bronchial asthma (BA) in residents of Siberia, Yakutia, and Russian Far East with mycotic sensitization. Materials and Methods. 45 BA patients in the age group of 24—58 year-olds have been checked. Among them 245 patients were residents of Amur region, 112 patients — residents of Novosibirsk region, and 86 — of the Republic of Yakutia (SAHA), the City of Mirniy. All the patients went through a complex clinical and allergological checkup. The results were processed with «STATISTICA 6» set of programs. Results of the research. Variation in mycotic sensitization in BA patients has proved to be region-bound. Conclusion. Mycotic sensitization in BA patients is marked by predominantly severe clinical course of bronchial asthma and high levels of IgE in the patients’ serum. In the Republic of Yakutia (SAHA) the number of such patients is higher than in Amur and Novosibirsk regions. In BA patients — residents of Amur and Novosibirsk regions — mycotic allergy is accompanied by the domestic one, while in Yakutia it is observed along with epidermal sensitization.
The publication provides an overview of the literature devoted to modern methods of diagnosis of malignant pleural mesothelioma (MPM). The analysis of medical records of 14 MPM patients who were treated in the Amur regional clinical hospital in 2009-2014 was done. One case is dealt with in detail. Difficulties in diagnosing MPM happen due to the following factors: the early symptoms of this tumor are not specific, and patients often seek help in the advanced stages; the difficulty of differentiation between benign diseases of the pleura and metastasis of other tumors in the pleura; not full availability of computed tomography (CT) and a VATS biopsy; insufficient awareness of primary care physicians about the features of MPM course. To improve the diagnosis of MPM it is recommended to perform CT of the chest as the primary method of diagnosis in individuals of 50 years old, especially in those exposed to asbestos in the past.
78Амурский медицинский журнал №3 -4 (15 -16) 2016and 0.3% in other locations. During the irst 12 hours from the time of the development of stroke patients who were in PSO: 54,5% in ischemic stroke (AI) and 59.6% in hemorrhagic stroke (GI). At admission impaired consciousness was identiied in 22.4% of patients, with 4%, Among patients with AI, the lesion is often localized in the vertebral-basilar pool, in the pool right artery and the pool left artery. In patients with GI lesions were more frequent in the right hemisphere of the brain and in the basin of the cerebellum. Most of the enrolled individuals included the following precursors of stroke: headache (92,6%), dizziness (66,6%), speech disorder (44,7%), nausea (35,6%), rise in blood pressure (32,5%), epistaxis (1.7 percent).To enroll in PSO, the average systolic blood pressure (SBP) of patients was 178, 3 mm Hg, mean diastolic blood pressure (DBP) is 97.4 mm Hg After the treatment of AD decreased the GARDEN to 137.6 mm Hg, DBP to 87.5 mm Hg. All patients had the risk factors (RF) such as hypertension and 97% of family history -84%, dyslipidemia -77%, obesity -67%, Smoking -68%, alcohol abuse 18%. Of the comorbidities identiied: AG -97%, cerebral atherosclerosis -69%, coronary heart disease -48%, atrial ibrillation -25%, chronic obstructive pulmonary disease -13%, diabetes 44%, respectively.In 55% of patients are often detected disturbing and depressing events. In 67% of patients, arterial hypertension was the third degree, 20% second, 13% the irst. The duration of hypertension averaged 10±1.7 years. Baseline antihypertensive therapy was received by only 14 people (14.7 per cent), episodic treatment was diagnosed in 23 patients (24,2%), 58 patients (61.1 %) have hypertension is not treated.Analysis of outcomes of hospitalization showed that the recovery выписано7,6%, improvement -78,8%, "no change" -0,6%. Death is set at 11.5% of patients.Thus, the obtained results can be used when planning measures for the prevention of cerebral complications of hypertension. Abstract The etiology of pneumonia, particularly in pregnant women and the efectiveness of antibiotic therapy in the period of epidemic inluenza in the Amur region were studied. 49 pregnant women with community-acquired pneumonia were examined and treated. 1. Inluenza A/H1N1swl in pregnant women is developing severety and is accompanied by a high rate of complications as pneumonia, respiratory distress syndrome, placental insuiciency and the formation of post pneumonic pulmonary ibrosis in the outcome. In pregnant women with viral-bacterial pneumonia occurred against the background of severe forms of inluenza A/H1N1 swl, you must apply the causal combination therapy: Relenza, oseltamivir treatment with antibiotics. One of the criteria for the efectiveness of the treatment is the dynamics of Leukocyte formula (an increase in the percentage of neutrophils). During the stages of intensive therapy, it was necessary to evaluate the hemostatic system and to make corrections of identiied hemocoagulation damages.
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