SummaryThe metabolism (uptake and degradation) of peroxynitrite-modified 13-VLDL and native 13-VLDL labeled with [t251]iodine was studied in monocytes isolated from peripheral blood of hypercholesterolemic (HC) and normolipidemic rabbits (NC). The peroxynitrite-modified 13-VLDL uptake and degradation was up to 2-fold higher in monocytes from HC rabbits than monocytes from NC rabbits. In addition, monocytes from HC rabbits took up and degraded significantly more peroxynitrite-modified 13-VLDL than native 13-VLDL. In contrast, monocytes from NC rabbits took up both lipoproteins in a similar rate and degraded more native 13-VLDL than peroxynitrite-modified 13-VLDL. Our results suggest that hypercholesterolemia can affect monocyte metabolism enhancing foam cell formation by increasing the influx of peroxynitrite-modified 13-VLDL.
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