547.972In the leaves of Pueraria h/rsuta L. (Thunberg kudzu bean), faro. Leguminosae, growing in Georgia we have detected six flay,hold compounds derived from quercetin and kaempferol [1], including a flavonoid glycoside, robinin, from which the antiuremic drug flaronin has been created [2].The individual flavonoid (1) crystallized out from a chloroform-purified aqueous alcoholic extract. By extraction with ethyl acetate, the mother liquor remaining after the separation of this compound yielded the total flavonoids, from which the individual compounds (1)-(4) were isolated.Flay.hold (1) --mp 192-193"C; [Ct]D 2° --83.5* (c 0.1; ethanol-DMFA 99:1), ~maxC2H5 °H, rim: 355, 265. This was decomposed by acid into an aglycon --kaempferol, with nap 274-278"C, D-galactose and L-rhamnose. The yield of the aglyeon was 36 %. Substance (1) was identified as robinin [2]. Flavonoid (2) --mp 182-186"C; [OdD 2° -26.5* (c 0.5; DMSO), kmaxC2H5 °H nm: 363, 255. This was decomposed by acid into quercetin with nap 302-305"C, D-glucose, and L-rhamnose. Flavonoid (2) was characterized as rutin [3, 5]. Flay.hold (3) --mp 181-184"C; [tX]D 2° --32.5 ° (C 0.5; DMSO); hmax C2HS°H, nm: 352, 266. This was decomposed into kaempferol and rutinose. Substance (3) was identified as nicotiflorin [3, 4].Flay.hold (4) --mp 239-242°C; [OdD 2° -23.1" (c 0.52; DMSO), kmax CH3°H, nm: 250, 260 sh. Acid hydrolysis formed the aglycon daidzein with mp 320-322"C and D-glucose. Substance (4) proved to be the isoflavone daidzin [3].The amount of robinin in the leaves of P. hirsuta was 1.7 %, of which 1.4% was isolated by direct crystallization. The considerable raw material resources of P. h/rsuta in Georgia and its high robinin content permit this plant to be recommended as an additional source of the drug flaronin [5].
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