115and can therefore be disregarded. When such a comparison is made the results are qualitatively similar and give strong support to the evidence already described.In the case6 of hemophilia the odds are enormously against the difference being due solely to chance (one to more than 2,000,000,000) and in the case of color blindness, in spite of the smaller numbers one to more than 500.
Statistical evidence, therefore, strongly indicates the presence of sex-linked lethal factors i n man. More complete evidence can be obtained only after an intensive study of several generations of proli$c families has been made. The theoretical and practical importance of making such studies is so great that a start on them should be made at the earliest opportunity.In a study of pathological conditions of the capillaries, and the effects of these conditions on the body as a whole, we have sought for some agents which produce widespread capillary damage. There is a considerable number of substances classed as capillary poisons. Some of these, for example histamine, produce functional changes, others, such as uranium and diphtheria toxin, produce structural changes. If the change produced results in a damage to the capillary wall, there should be a decrease in its permeability. The tissue cells supplied by the capillary would receive less blood and oxygen, with a resulting abnormal metabolism. I t seemed to us that this effect might take the direction of an acidosis. The following figures, obtained from experiments on dogs, the Van Slyke apparatus being used for the alkali reserve determination, bear out this conception.
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