An inactivated vaccine against horse strangles was developed based on the Streptococcus equi strain “N-5/1”, which has sufficient efficacy and environmental safety. The vaccine was tested in accordance with the order of the Ministry of Agriculture of the Russian Federation No. 101 dated March 6, 2018 “On approval of the rules for preclinical studies of a medicinal product for veterinary use, clinical study of a medicinal product for veterinary use, and bioequivalence of a medicinal product for veterinary use”. According to the results of the tests, the absence of toxicity and irritating activity during intragastric administration of the vaccine to white mice at the maximum permissible dose (1 cm3) was established. The vaccine withstands the test for pyrogenicity, does not cause an increase or decrease in body temperature in animals during the observation period. A sufficiently high immunogenicity in laboratory animals of an inactivated vaccine was determined with a single injection (up to 80%), which meets the general requirements for the immunogenicity of microorganism strains in the composition of inactivated vaccines.
научно-исследовательский институт сельского хозяйства имени М.Г. Сафронова, г. Якутск 2 Якутская государственная сельскохозяйственная академия, г. Якутск 3 Всероссийский институт экспериментальной ветеринарии, г. Москва ИНФОРМАЦИОННАЯ КОМПЬЮТЕРНАЯ БАЗА ДАННЫХ «МЫТ ЛОШАДЕЙ» В статье рассматриваются способы разработки компьютерной базы данных «Мыт лошадей», позволяющий сократить затраты рабочего времени для освоения предмета студентами техникумов и высших учебных заведений, а также принятия своевременной диагностики, профилактики мыта лошадей с одновременным повышением качества обучения и принятых мер. Ключевые слова: лошади, мыт, эпизоотология, диагностика, профилактика. The article discusses ways to develop a computer database "Strangles in Horses" that allows to reduce the costs of working time for students and technical schools to master the subject, as well as taking timely diagnosis and prevention of Strangles in horses while improving the quality of training and measures taken.
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