1988. The effect of a weight-reducing diet on the nitrogen metabolism of obese adolescents. Can. J. Physiol. Phamacol. 66: 1469-14'74. Rates sf whole body amino nitrogen flux were measured in 16 obese adolescents undergoing weight reduction with a high protein low energy diet. The subjects received approximately 2.5 g of animal protein per day per kilogram ideal body weight and maintained nitrogen balance throughout the 18 days on the diet. Flux rates were calculated separately from the cumulative excretion of ' 5~ in urinary ammonia and urea following the administration of a single dose of ['5~]glycine. The pattern of 15N label appearance in urinary ammonia and urea nitrogen was followed for 72 h after the administration of [ ' %~]~l~c i n e . Significant amounts of label continued to be excreted in both urinary ammonia and nitrogen for 36-48 h after label administration. The weight-reducing diet accelerated cumulative excretion in urinary urea, but not in ammonia nitrogen compared with the control diet. Whole body nitrogen flux rates increased rapidly and significantly on the diet. Using the urea end product, this increase was evident on the 4th diet day, but not by the 7th or subsequent days. On the other hand, using the ammonia end product, flux rate increased markedly (g < 0.0001) and remained elevated throughout the whole study. Our results demonstrate adaptive changes in whole body amino-nitrogen metabolism in response to the reducing diet. Different patterns of change are seen depending upon whether an ammonia or a urea end product is used. Our data thus add to the evidence for compartmentation of the body's amino-nitrogen pools.PENCHAWZ, B. B . , CLARKE, W., ARCHIBALD. E. H., et VAISMAN, N. 1988. The effect of a weight-reducing diet on the nitrogen metabolism of obese adolescents. Can. J. Physiol. Bhmacol. 66 : 1469-1474. On a determink le taux d'azote armint corporel chez 16 adolescents obkses sournis r'p une rkduction de paids avec une dikte 8 faible teneur tnergttique riche en prottines. Les sujets ont r e p approximativement 2'5 g de proteine animale, par jour par kilogram de poids corporel idtal, et ont maintenu un equilibre azote slurant les 18 jours de la diCte. Le taux kt6 calculd a partir de 19excr6tion cumulative de "N dans l'ammoniac et h partir de 17urke urinaire apks l'adrninistration d'une seule dose de [15~]gllcine. Lea taux de "N dans I'arnmoniac et l'azote urtique urinaires ont t t t observks pendant 72 h apres I'administration de la [ %~)~l~c i n e .Des quantitts significatives du compost ont continut a Ctre excktees tant dans l'ammoniac que dans I'azote urinaires pendant 36-48 h aprhs son administration. La dikte amaigrissante a acctlCrk l'excretion cumulative de 1 5~ dans l'urke urinaire, mais dans l'azote ammoniacal, comparte a la diCte ttmoin. Ee taux d'azote corporel a augment6 rapidement et significativement pendant la dikte. En consideration l'urte comme produit terminal, cette augmentation a ete manifeste le 4" jour de la dikte, mds non aprks le 6'jour. Par ailleurs, en consid...
Seventeen obese adolescents were treated with the protein-sparing modified fast (PSMF), a high-protein, low-carbohydrate, low-calorie diet, for approximately 3 mo and then followed for a total of 12 mo. The diet provided a mean of 880 kcal.kg-1. d-1 and 2.5 g protein. kg IBW-1. d-1. Body composition was determined using four skinfold measurements, total body potassium (TBK), and total body nitrogen (TBN) at baseline, 3 mo, and 12 mo. Twelve subjects returned for follow-up at 1 y (71%) and 48% had sustained weight loss with the percentage ideal body weight for height decreased from 154 to 125 over the year. Six subjects had TBK and TBN measured and TBK decreased 13.0% and TBN decreased 14.3% over the year. This reflected a change toward normalization of the predicted TBK from 121 to 102% and TBN from 119 to 102%.
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