A new nano-hybrid material prepared by physical mixing of the components was used in biomedical applications where three samples of the prepared materials were used to determine the best composition as an antibacterial and anticancer agent in addition to its use as an antifungal agent. In the case of antimicrobials, two types of bacteria were used: Staphylococcus aureus and Escherichia coli and one type of fungus was used: Candida albicans. The area of inhibition was calculated after using the hybrid material of 2.5% titanium oxide with iron oxide, which gave better results than pure iron oxide and that mixed with 5% titanium dioxide.

In this investigation, the nanocomposites were synthesized using the physical mixing technique. This technique involved adding 20% titanium dioxide (TiO2) to a combination of PMMA and PVA in terms of weight percentages. The physical properties of prepared nanocomposite have been examined by using scanning electron microscope, X-ray diffraction technique XRD, Fourier transformed infrared spectrometry (FTIR) and UV–Vis spectroscopy. XRD patterns specified that the prepared composite was mostly crystalline in nature. Scanning electron micrograph showed that TiO2 nanoparticles were covered with a polymer blend matrix. FTIR results confirmed the presence of PVA and PMMA groups on the surface of TiO2 NPs. The MTT assay method was utilized on the MSF-7 cell line in order to evaluate the potential anticancer properties of the produced components. The nanocomposites showed good activity on cancer cells.

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