Objectives: To determine whether the mitochondrial DNA (mtDNA) A4336G mutation represents a risk factor for Spanish patients with both Alzheimer’s disease (AD) and Parkinson’s disease (PD). Material and Methods: One hundred and sixty-one AD and 106 PD unrelated patients were included in the study. Seventy-eight age-matched and 144 randomly chosen healthy subjects served as controls. The frequency of the A4336G mutation in these groups was compared using the χ2 and Fisher’s exact tests. p < 0.05 was established as a statistically significant differential value. Results: The mtDNA A4336G mutation was present in 1/161 of AD patients (0.6%), in 3/106 of PD patients (2.8%), in 1/78 of age-matched controls (1.3%) and in 2/144 of the randomly chosen controls (1.4%). These differences were not statistically significant. Conclusion: Our results do not support the hypothesis that this mutation represents a risk factor for either AD or PD patients, at least in the case of this Spanish sample.
Noncommunicating cysts of the septum pelludicum are rare and diagnostic experience with CT scan is scanty. They may cause hydrocephalus because of obstruction of Monro’s foramina. In this report we describe a young patient with acute Korsakoff’s syndrome. The CT scan revealed a cyst of the septum pellucidum without hydrocephalus. Surgery disclosed a noncommunicating cyst compressing structures of the limbic system. After surgery symptoms disappeared.
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