IFNs are a family of natural multifunctional glycoproteins with a multitude of antitumor effects including inhibition of cell proliferation, induction of cell differentiation, upregulation of class I major histocompatibility complex antigens, inhibition of angiogenesis, and establishment of a T-helper 1 (Th1) type response [1, 2]. IFN- sensitizes human malignant glioma cells to CD95Linduced apoptosis [3] down-regulates the expression of the proangiogenic molecules, such as basic fibroblast growth factor (bFGF), IL-8, and matrix metalloproteinase (MMP)-2 and-9 and inhibits the motility of vascular endothelial cells in vitro and angiogenesis in vivo [4]. IFN- has strong anti-proliferative effects in glioblastoma cell lines and in vivo glioma cells expression of IFN- result in a significant inhibition of tumor growth [5, 6]. IFN- upregulates several mediators of apoptosis in astrocitomas
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