Based on the variables identified above, further studies are needed to determine whether the inflammatory response of the host represents only a marker of the severity of gastrointestinal infection or whether, alternatively, it is a pathophysiologic factor that leads to HUS.
Pacemaker location in the abdominal wall is considered a contraindication to videocapsule endoscopy (VCE). The aim of this study was to review our experience on the use of VCE in patients with a pacemaker located in the abdominal wall. VCE was carried out with monitoring of cardiac rhythm. This was a retrospective review of VCE case studies performed at two tertiary care university medical centers (pediatric and adult). The main outcome measures were adverse events and quality of VCE images. No adverse events were experienced in any of the five patients with implanted cardiac pacemakers, including the two with abdominal pacemaker. No interference with the VCE recording was observed during the studies, although the capsule was observed to be briefly inactivated by the pacemaker in one case. The present study, though small, suggests that VCE is safe in adult and pediatric patients who are fitted with cardiac pacemakers, even when implanted in the abdominal wall. The VCE exam can be carried out successfully under close supervision. Dysfunction of the capsule appears to be more likely than problems with cardiac pacing.
This case provides clinical and radiological evidence supporting an association between ascending cholangitis and acute intrahepatic portal vein thrombosis.
, et al. Acute liver failure from Wilson's disease in a five-year-old child. Can J Gastroenterol 1993;7(8):610-612. A five-year-old child presented with acute liver failure with jaundice, hemolysis, ascites, encephalopathy and coagulopathy. A diagnosis of fulminant Wilson's disease was made on the basis of elevated serum and urinary copper, and the simultaneous diagnosis of Wilson's disease in an older sibling. Despite supportive therapy, liver function remained precarious and the patient underwent a successful orthotopic liver transplant. This is one of the youngest children reported with fulminant liver failure from Wilson's disease and underlines the need to entertain the diagnosis in children presenting with liver failure even at this early age.
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