The effect of certain local anaesthetics on barbiturate sleep in the mouse and the guinea pig is described. One of a series of new local anaesthetics 1‐(1‐methyl‐2‐phenylcarbamoylethyl)pyrrolidine (WS 10) prolongs barbiturate sleep in the guinea pig 2.3 times at the optimal dose without obvious side effects; other closely related members of the same series diminish barbiturate sleep.
The authors report immediate complications when using artificial pneimothorax (i.p.) based on the processing of questionnaire material for more than 250,000 injections made by doctors in Swiss sanatoriums.
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