Summary Background Addressing childhood obesity in Latin America requires a package of multisectoral, evidence‐based policies that enable environments conducive to healthy lifestyles. Objective Identify and examine key elements to translating research into effective obesity policies in Latin America. Methods We examined obesity prevention policies through case studies developed with an expert in the specific policy. Policies were selected based on their level of implementation, visibility and potential impact to reduce childhood obesity. They include: (i) excise taxes on sugar sweetened beverages and energy‐dense foods; (ii) front‐of‐package food label legislation; (iii) trans fatty acids removal from processed foods; and (iv) Ciclovías recreativas or ‘open streets’. Case studies were coded to identify components that explained successful implementation and sustainability using the Complex Adaptive Health Systems framework. Results The analysis identified key elements for effective and sustainable policy, including evidence justifying policy; evidence‐based advocacy by civil society; political will; and legislation and skillful negotiations across government, academia, the private sector and civil society. Scientific evidence and evaluation played an important role in achieving tipping points for policies' launch and sustain effective implementation. Conclusions Well‐coordinated, intersectoral partnerships are needed to successfully implement evidence‐based anti‐obesity policies. Prospective policy research may be useful for advancing knowledge translation.

The causes of obesity worldwide are complex and multilevel, including changing food environments, physical activity levels, policies, and food production systems. This intricate context requires multilevel and multicomponent (MLMC) interventions to improve health outcomes. We conducted a literature review of MLMC interventions for obesity prevention and mitigation; 14 studies meeting search criteria were identified. We found examples of successes in preventing obesity, reducing overweight, improving healthful behaviors, and enhancing some psychosocial indicators. Of eight studies that reported health and behavioral results, five showed no significant impact and three showed reductions in obesity. Four studies showed significant improvement in dietary behavior, and five reported significant desirable effects in physical activity or screen time. Five studies reported psychosocial impacts, and three of these showed significant improvements. MLMC approaches show promising results, particularly when they are able to integrate components at the policy, community, and interpersonal levels.

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