As shown by an increase in plasma corticosterone concentrations, adenosine administration stimulated pituitary-adrenocortical activity. This effect was prevented by dexamethasone (2 mg/kg i.p.). Added in vitro, adenosine reduced both adrenal basal and adrenocorticotropic hormone (ACTH)-stimulated corticosterone release, while it stimulated pituitary ACTH release. This ACTH response was blocked by dexamethasone but not by Tyr-somatostatin. Restraint stress increased adenosine content in the anterior pituitary, suggesting its possible involvement in hormonal stress response. Because the effect of adenosine on plasma corticosterone was still present in rats with a pharmacological block of the endogenous corticotropin-releasing factor release, we propose that adenosine is involved in the regulation of adrenocortical secretion at the level of the anterior pituitary and that this role is exerted through an interaction with a stimulatory adenosine receptor.
1972. Effect of hippocampal stimulation on the plasma thyrotropin (TSH) and corticosterone responses to acute cold exposure in the rat. Can. J. Physiol. Pharmacol. 50, 364-367.Seven days after the stereotaxic implantation of a bipolar electrode in the gyrus dentatus of the hippocampus of adult male rats, exposure to cold (20 rnin at -5 "C) increased both plasma TSH and corticosterone concentrations, whereas exposure in association with a minor environmental disturbance (presence of an observer) suppressed the TSH response to cold and enhanced the corticosterone response. Concurrent stimulation of the hippocampus with monophasic square waves of 6.3-1 -5 V, 10 c.p.s., and 0.1 ms duration was found to restore the TSH response to cold and to inhibit the secretion of adrenocorticotropin (ACTH) (as reflected by the plasma corticosterone concentration). These findings suggest that the concurrent stimulation of ACTH release and inhibition of TSH secretion induced by nonspecific stress are possibly related to depressed hippocampal activity.DUPQNT, A., BASTARACHE, E., ENDR~CZI, E., et FORTIER, C. 1972. Effect of hippocampal stimulation on the plasma thyrotropin (TSH) and corticosterone responses to acute cold exposure in the rat. Can. J. Physiol. Pharmacol. 50, 364367.
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