Supplementing the traditional clinical and postmortem analysis with an assessment of the preventability of perinatal loss makes it possible to ensure a unified approach to evaluating these conditions and the comparability of autopsy results in different subjects of the Russian Federation and to determine regional reserves for reducing perinatal mortality rates.
Introduction Novel coronavirus infection (NCI) COVID-19 in women during pregnancy has a different course – from asymptomatic to severe and extremely severe. Associations between the severity of NCI COVID-19 and the serum level of 25-hydroxycalciferol (25(OH)D), which is an active metabolite of vitamin D, are currently being studied. There are few data on the association of vitamin D deficiency with severe NCI in the general population, even less data reflecting the level of 25(OH)D in the blood serum of pregnant women suffering from NCI of varying degrees of severity. Purpose of research was to conduct clinical laboratory comparisons, including the level of the active metabolite of vitamin D 25-hydroxycalciferol in the blood serum of pregnant women with COVID-19 NCI of varying degrees of severity. Materials and methods. Under observation there were 29 pregnant women living in Chelyabinsk and Chelyabinsk region, who were admitted to the maternity obstetric service of the infectious hospital for patients with NCI COVID-19 during the 3rd–4th wave of the pandemic. Group 1 consisted of 16 pregnant women with severe NCI COVID-19. Group 2 included 13 pregnant women with mild NCI COVID-19. Serum 25(OH)D levels in these patients were determined by chemiluminescent immunoassay. Results. The patients with severe NCI COVID-19 are statistically more likely to be deficient in vitamin D, while adequate levels of the latter are not recorded. Discussion. Vitamin D deficiency may contribute to a more prominent systemic response with the development of a cytokine storm and cause a severe course of NCI COVID-19. Conclusions. The conducted research demonstrated the relationship of vitamin D deficiency with the severity of NCI COVID-19 in pregnant women. We suggest that vitamin D deficiency can be considered as a predictor of the severe course of NCI COVID-19.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.