a b s t r a c tIn this paper, we investigate the positive influence dominating set (PIDS) which has applications in social networks. We prove that PIDS is APX-hard and propose a greedy algorithm with an approximation ratio of H(δ) where H is the harmonic function and δ is the maximum vertex degree of the graph representing a social network.
Abstract. Online social network has developed significantly in recent years as a medium of communicating, sharing and disseminating information and spreading influence. Most of current research has been on understanding the property of online social network and utilizing it to spread information and ideas. In this paper, we explored the problem of how to utilize online social networks to help alleviate social problems in the physical world, for example, the drinking, smoking, and drug related problems. We proposed a Positive Influence Dominating Set (PIDS) selection algorithm and analyzed its effect on a real online social network data set through simulations. By comparing the size and the average positive degree of PIDS with those of a 1-dominating set, we found that by strategically choosing 26% more people into the PIDS to participate in the intervention program, the average positive degree increases by approximately 3.3 times. In terms of the application, this result implies that by moderately increasing the participation related cost, the probability of positive influencing the whole community through the intervention program is significantly higher. We also discovered that a power law graph has empirically larger dominating sets (both the PIDS and 1-dominating set) than a random graph does.
We investigated the dynamics of a gene regulatory network controlling the cold shock response in budding yeast, Saccharomyces cerevisiae. The medium-scale network, derived from published genome-wide location data, consists of 21 transcription factors that regulate one another through 31 directed edges. The expression levels of the individual transcription factors were modeled using mass balance ordinary differential equations with a sigmoidal production function. Each equation includes a production rate, a degradation rate, weights that denote the magnitude and type of influence of the connected transcription factors (activation or repression), and a threshold of expression. The inverse problem of determining model parameters from observed data is our primary interest. We fit the differential equation model to published microarray data using a penalized nonlinear least squares approach. Model predictions fit the experimental data well, within the 95 % confidence interval. Tests of the model using randomized initial guesses and model-generated data also lend confidence to the fit. The results have revealed activation and repression relationships between the transcription factors. Sensitivity analysis indicates that the model is most sensitive to changes in the production rate parameters, weights, and thresholds of Yap1, Rox1, and Yap6, which form a densely connected core in the network. The modeling results newly suggest that Rap1, Fhl1, Msn4, Rph1, and Hsf1 play an important role in regulating the early response to cold shock in yeast. Our results demonstrate that estimation for a large number of parameters can be successfully performed for nonlinear dynamic gene regulatory networks using sparse, noisy microarray data.Electronic supplementary materialThe online version of this article (doi:10.1007/s11538-015-0092-6) contains supplementary material, which is available to authorized users.
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