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tasks (3), regardless of whether the injury was in the right or left hemisphere, or in the frontal, parietal, temporal, or occipital lobes. The deficit on the Army General Classification Test turned out to be comparatively focal (1), and so were a number of other changes in performance, such as difficulty with route finding (4), which was limited to the group with parietal penetration.The work of Lashley (5) and others on subhuman mammals can be similarly interpreted. For certain complex tasks, such as the maze, Lashley found general (nonlocalized) effects of cortical removals in rats. With other tests, in the same animals, he found focal changes such as alterations in brightness habit after occipital removals, and difficulties on a "double platform box" after anterior removals. Thus, specific and general effects coexist after cerebral lesions in man, as well as in subhuman forms; which of these effects appears to predominate depends on the nature of the tests employed. If the range of the tasks is sufficiently extended, one finds specific and general effects in obligatory association.

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Most of the methods used for the production of experimental renal hypertension involve a reduction in the amount of functional renal tissue. According to the renotrophin hypothesis, the blood pressure of animals with experimental hypertension should be reduced or normalized if the rate of production of renotrophin is reduced (hypophysectomy, thyroidectomy, low protein diet) or if the functional renal mass is increased (kidney transplant, parabiosis). Conversely, the blood pressure should rise to higher levels or hypertension develop if the rate of production of renotrophin is increased (thyroid hormones, somatotrophin, testosterone, thyrotrophin, gonadotrophin in males, protein-rich diets) or if the functional renal mass is further reduced (sensitizing actions of unilateral nephrectomy, etc.). Experimental evidence to be presented conforms with the renotrophin hypothesis and its 4 corollaries.