The proportions of preterm and post-term births increased while the average birth weight in term infants decreased over the 20-year period of observation. Further research should address those factors that could explain the observed pattern of pregnancy outcomes in the Komi Republic.
Perinatal lesions of the Central nervous system (CNS) in newborns occupy a leading place in the structure of perinatal morbidity and subsequent disability of children. To identify the features of the content of sRAGE in pregnant women with threatening preterm labor (UPR) in the period of 22-27 weeks, who subsequently gave birth to children with perinatal CNS lesion. Serum of venous blood of pregnant women with UPR at the term of 22-27 weeks was determined by ELISA once the content of sRAGE. If the value of sRAGE in pregnant women is 659.5 PG/ml or less, perinatal hypoxic lesions of the Central nervous system in newborns are predicted with an accuracy of 75.8% (sensitivity of 82.6%, specificity of 66.7%).
Based on firstly created Komi database of 1980- 1999 years, the authors analysed labor and delivery outcomes: total amount, newborns height and weight, Apgar score, term of pregnancy in dependence on seasonal and yearly changes. Received data testified that seasonal transformation of human organism in European North conditions along social-economic and medical factors have possible influence to conception, pregnancy and delivery outcomes.
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