The prior treatment of guinea pigs with nicotinamide diminished the symptoms of experimental bronchial asthma and the intensity of anaphylactic shock. Nicotinamide was also found to inhibit anaphylactic mast cell degranulation in mice and histamine release from rat-isolated peritoneal mast cells by compound 48/80. The role of nicotinamide in bronchial asthma is discussed.
grossly similar in the different regions, suggesting, nevertheless, a possibly higher density of histaminergic terminals in the rostral parts of the brain; but this method has not so far allowed the determination of the regions rich in histaminergic cell-bodies or nerve terminals.
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