The low frequency antigen Orriss (Or) was found on the erythrocytes of a healthy blood donor. A subsequent family investigation showed Or to segregate independently of the Rh, Colton and Kidd blood group systems; however, it appeared to be inherited with the Ms gene complex. Studies carried out demonstrated that sialoglycoproteins (SGPs) extracted from Or+ erythrocytes specifically neutralize anti-Or and that all Or+ individuals tested carry an M antigen which is more resistant to trypsin treatment than the M antigen of Or- erythrocytes. These results lead to the conclusion that the Or antigen is found on a variant alpha-SGP and its presence renders this molecule more resistant to trypsin than normal.

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Abstract. A three‐generation consanguineous Caucasian family in which 2 siblings have autosomal recessive cataracts and the phenotype I negative, i positive is described.

This paper describes the association of the low-frequency antigen Lsa with high-molecular-weight variants of β- and γ-sialoglycoproteins (β-SGP, γ-SGP). The variant β-SGP, designated β^Ls^a, carries the Ge^3 epitope and the epitopes recognised by 3 murine monoclonal anti-β-SGP antibodies. The variant γ-SGP, designated γ^Ls^a, carries the Ge^2 and Ge^3 epitopes. Both β^Ls^a and y^Ls^a showed enhanced reactions in immunoblotting with anti-Ge3 sera - which may indicate the presence of 2 Ge3 epitopes on β^Ls^a and γ^Ls^a These findings would be consistent with the proposed structure of the Ls^a glycophorin C gene.

This paper presents the results of a study on the erythrocyte membrane proteins from Webb-positive individuals. The membrane proteins were separated by polyacrylamide electrophoresis and stained using a Silver stain as well as Coomassie blue and PAS stains. All Webb-positive individuals exhibited a decrease in the beta-sialoglycoprotein beta SGP band along with the appearance of a new SGP 3,000 daltons less than beta SGP. It is postulated that this band is an abnormal beta SGP possibly lacking the N-linked oligosaccharide that is normally present in beta-SGP.