The effects of lactose and microcrystalline cellulose on the flowability and moldability of a tabletting mixture and the quality of tablets obtained by direct pressing have been investigated. The optimum composition of a complex filler for direct pressing of tablets is proposed. The possibility of replacing the technology of wet granulation by direct pressing for five well-known medicinal preparations is established.
Steroids U 0300Reactions of 5-Diazoimidazoles with Steroid Hydrazones. -The reaction of 5-diazoimidazoles, e.g. 5-diazo-4-nitroimidazole, with steroidal hydrazones such as (I) gives rise to corresponding imines [cf. (III)] instead of the desired tetrazenes [cf. (II)] due to the instability of compounds (II). -(SADCHIKOVA, E. V.; KURENEVA, E. A.; SHTOKAREVA, E. A.; SELEZNEVA, I. S.; Chem. Heterocycl.
Reaction of AromaticDiazo Derivatives with N-Acetyltyrosine Methylamide. -Reaction of N-acetylthyrosine methylamide (IV) with the diazonium salts (V) produces the azo compounds (VI). -(NIFONTOV, V. I.; BEL'SKAYA, N. P.; KRUPNOVA, L. V.; KHVOROVA, N. M.; BOBARYKINA, M. A.; SHTOKAREVA, E. A.; Khim. -Farm. Zh. 24 (1990) 8, 53-55; Ural. politekhn. inst. im. Kirova, Sverdlovsk, USSR; RU)
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