Introduction. Renal malignancies accounted for 3.9% of all malignant neoplasms in Russia in 2019 and were among the top ten most common. Paraneoplastic syndrome can occur in malignant neoplasms and manifest as paraneoplastic nephropathies and glomerulopathies. The aim of the study was to analyze archival renal specimens to assess the incidence of glomerulopathies in renal neoplasms. Materials and methods. We analyzed 122 kidney samples with a tumor after nephrectomy in Krasnoyarsk regional clinical oncologic hospital named after A.I. Kryzhanovsky. To assess the cellular composition of the glomeruli and basement membrane structure, the following histochemical stains were used: PAS reaction, Masson’s trichrome stain, methenamine silver, and congo red stain. Results. The age of the patients ranged from 28 to 84 years. Malignant neoplasms were diagnosed in 114 cases (93.4%), whereas benign neoplasms were detected in 8 patients (6.6%). Fifty-six cases (45.9%) showed glomerulopathies. In 55 cases, glomerulopathies were found in malignant neoplasms (98.2%) and one case was found in a patient with a benign neoplasm (1.8%). Diabetic nephropathy was detected in 43 cases, ac-counting for 76.8%. Glomerulonephritis was diagnosed in 7 patients (12.5%) and focal segmental glomerulosclerosis was revealed in 6 cases (10.7%). Conclusion. Glomerulopathies in renal tumors are rather common and therefore their diagnosis is important in the study of the operative material. Keywords: kidney, tumour, glomerulopathies, paraneoplastic syndrome, diabetic nephropathy, glomerulonephritis
Light chain proximal tubulopathy (LCPT) is a disease characterised by accumulation of monoclonal immunoglobulins produced by tumour clones of plasma cells or B-lymphocytes in the epithelium of proximal renal tubules. One of LCPT forms is the crystal one, against the background of which epithelium of proximal renal tubules accumulates crystal structures of different sizes and shapes. This work presents an observation of a kidney transplant patient with crystal LCPT. The patient was admitted with azotaemia and underwent renal biopsy in order to establish the diagnosis. Morphological analysis drew attention to necrosis of epithelium of proximal renal tubules. Electron microscopy visualised crystal structures, immunohistochemical analysis of which revealed their monotypy in relation to lambda light chains of immunoglobulins. LCPT was diagnosed based on the comparison of the morphological picture and clinical data.
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