Acute Respiratory Infection causes symptoms that last for 14 days usually asymptomatic or mild to severe and fatal disease depending on the cause environmental factors and host factors. This study aims to determine the relationship of residential density and ventilation area with the incidence of respiratory infection. This research method is an observational study with cross sectional design. The population in this study were all residents who lived in 24 Ilir Bukit Kecil Palembang namely 196 housing units and a sample of 66 samples and sampling techniques with simple random sampling. The results showed that 69.7% of respondents experienced respiratory Infection. Based on statistical tests it was found that there is a relationship between the area of the room with respiratory infection with p value = 0.003 (p <0.05) there was a relationship between occupancy density and respiratory infection p value = 0.003 (p <0.05) had a relationship and ventilation has no relationship with the incidence of respiratory infection with p value = 1,000 (p> 0.05) so it can be concluded that the area of the room and occupancy density has a relationship with the incidence of respiratory infection.
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