No abstract

NCT01724528.

Abandoned mines can pose a major environmental hazard. At the beginning of the 21st century, significant steps were taken all around the world in order to protect these historically valuable complexes, and the mining heritage was recognized as a potential for the development of alternative tourism. This exploration covers mines in the Kopaonik Mountain area. Mining on this mountain began in ancient times. It has developed throughout history, and today only one mine is active. Three abandoned (Gvozdac, Suvo Rudište and Raičeva Gora) and one active mine (Belo Brdo-Zaplanina) are the subject of research. The basic aim of the research is twofold. The estimation of geo-tourist values was performed using the Geosite Assessment Model (GAM), and the ecological status assessment WAS performed according to the standard model based on negative and positive values. Based on the applied methods, it was concluded that mines (geosites) have a high level of natural characteristics, and that differences between geosites are evident in tourist values. The reason for this is insufficient tourist affirmation and the insufficient availability of tourist infrastructure. With the ecological status, positive values were observed on the geosites, which also differ from one (Raičeva Gora) to 15 points (Gvozdac). In the end, the results obtained are of great scientific importance, and their direct application is in the development of the Tourism Development Strategy in the Kopaonik area.

No abstract

In the paper, the aridity is defined on the basis of four climate indices: De Martonne's index of aridity, Lang's Rain Factor and Gračanin's Rain factor for the vegetation period and hydrothermal coefficient of Seljaninov. While the annual value of the drought index (I DM) shows humid characteristics, the monthly values show the variability of the conditions. The summer months (July and August) are classified as semi-arid months, while the winter months (December-February) are extremely humid. The spatial distribution of the isoarids indicates that the northern part of the basin has the characteristics of a semiarid climate, while the southeastern parts are more humid. The analysis of mean annual values of the drought index indicates in semiarid conditions (1990 and 2000), but also the humid conditions (2005 and 2009). A positive linear trend indicates that there is a tendency towards humid conditions. The significance test confirms the existence of a statistically significant trend. During the vegetation period, semi-arid conditions are present (July-August). April is slightly humid, and October is moderately arid. The Lang's Rain Factor (KFg) characterizes basin climate as semiarid, while the Gračanin rain factor for the vegetation period (KFm) indicates a moisture deficit in the summer months. Hydrothermal coefficient Seljaninova (HTC) indicates a lack of moisture in July and August. Vegetation period is characterized as insufficiently humid. Irrigation is one of the most important measures for solving drought problems, since the yield varies from year to year.

The aim of this research was to determine the serum dipeptidyl peptidase IV (DPPIV) activity as well as the percentages of CD26 + lymphocytes and CD26 + overall white blood cells in patients with hematological malignancies: non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), leukemia, plasmacytoma and multiple myeloma, and in healthy individuals. Data from our study showed significantly decreased serum DPPIV activity and a significant decrease in the percentage of: CD26 + lymphocytes, CD26 + overall white blood cells and lymphocytes in patients with NHL in comparison to healthy controls. Patients with leukemia had a statistically significant lower activity of DPPIV in serum and significant decrease in the percentage of CD26 + lymphocytes in relation to healthy controls. Furthermore, significantly decreased DPPIV serum activity associated with a significantly reduced percentage of CD26 + overall white blood cells and percentage of lymphocytes was found in patients with multiple myeloma when compared to the healthy control group. The obtained results indicate that immune disturbances that can occur in hematological malignancies might be related to the decreased expression and activity of CD26/DPPIV that we observed.

Recent climate changes cause significant natural and socio-economic consequences. They represent one of the major environmental problems of the late 20th and early 21st centuries. Changes in temperature and precipitation play a significant role in understanding climate change issues. They include numerous extreme climatic events such as heat waves, droughts, forest fires and more. Looking at regional differences in temperature and precipitation regime change, Southern Europe, including the Republic of Serbia, occupies a special place. The Mačva district (3.272 km²) is almost four times as spacious as the Mačva area. The administrative-political division of the Mačva district is comprised of eight municipalities. The paper presents trends of two climate variables: mean annual air temperature and mean annual precipitation in the study area. In methodological sense, the main statistical procedure is the non-parametric Mann-Kendall (MK) test. Data from three available meteorological stations in the Mačva district (1949-2015) were used for the analysis. The presented results of the trends in air temperature indicate that there is a statistically significant positive trend in all-time series. In trends, precipitation amounts a statistically significant positive trend was observed in two time series, while in one there is no trend. The expressed trends, especially in the case of air temperatures, lead to the possibility of drought. Mačva district and Mačva have some agricultural importance in the Republic of Serbia. For these reasons, some adaptation to climate change is needed as arid conditions lead to fluctuations in agricultural yield.

A more complete climate image of a site is obtained by analyzing bioclimatic indicators. In this paper, an analysis of the physiological sense of heat in the territory of the city of Kragujevac was presented. Bioclimatic considerations are based on the equivalent temperature, which represents the combined influence of air temperature and water vapor pressure. Based on these two climatic elements, the corresponding equations and the Krüger anthropo-climatic classifications, three climate types and nine physiological sensations of heat for the territory of the city of Kragujevac were isolated. Their significance in bioclimatology is that they cause different sensations of heat in healthy and sick people, and can serve as the basis for the expected types of bioclimate during the year. Urban areas are areas of higher population concentration to which the climate elements act stimulating or, on the contrary, discouraging, which depends on the person's health. For the needs of this work, a thirty-year climate period (1981-2010) was analyzed based on the data obtained from the weather station Kragujevac. There are significant historical and tourist sites and natural resources in the city and its surroundings, which can be valorized complementarily. Analyzed values of equivalent temperatures can be used for the planning of tourist activities and in means of tourist propaganda. For this purpose, this work can be a solid bioclimatic basis.