This paper reports the way for the synthesis of nanoplate VO2 (B) particles with controlled morphology. Nanoplate VO2 (B) particle was synthesized by hydrothermal method. Microstructure of VO2 (B) particles were controlled by hydrothermal temperatures and use of Zn doping into VO2 (B) matrix. The microstructure of the particles was shifted from nanowires to nanoplate morphology by changing of hydrothermal temperatures. The doping of Zn into VO2 nanoparticles resulted in an effective achievement of VO2 (B) phase. In addition, luminescence of VO2 (B) nanoparticle was also controlled by the use Zn doping. These results suggest that the potential application of Zn doped VO2 (B) particles for potential application in optical and energy techniques.
TiO2 nanotubes were successfully synthesized by electrochemical method. A fluoride salt mixture was used as an electrolyte for synthesizing TiO2 nanotubes on titanium substrates. In this work, we have reported the synthesis procedure of TiO2 nanotubes and investigated the corrosion resistance of TiO2 nanotubes coated on the Ti substrate. FE-SEM was used to observe the morphology and determine the size of the TiO2 nanotubes. The phase formation and crystal quality of TiO2 nanotubes were studied by XRD measurements. One-microliter distilled water droplets were used to define the wettability of the TiO2 nanotube surfaces by measuring the contact angle. The corrosion resistance behavior of specimens was analyzed in the simulated body fluid solution (SBF) using potentiodynamic polarization tests for potential application as implants.
A magnetic nanocomposite, using a Nopal cactus-derived biopolymer in combination with NH4OH-modified cobalt superparamagnetic (CoFe2O4) nanoparticles, was developed as a green flocculant system for recovery of microalgae from aqueous solutions. The obtained magnetic nanomaterials were subsequently dispersed in the biopolymer matrix with the support of ultrasonic waves. The effects of various factors on pectin extraction, fabrication of nanocomposites, and the flocculation process of microalgae were also studied. The characteristics of the obtained materials (pectin, modified magnetic nanoparticles, and nanocomposites) were evaluated via X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric-differential scanning calorimetry, Fourier transform infrared spectroscopy, and zeta potential analysis. The optimal conditions for pectin extraction from Nopal cactus, as well as the fabrication of magnetic nanoparticles, modified magnetic nanoparticles, and nanocomposite were reported. The characteristic data of the fabricated materials showed heat resistance and abundant surface functional groups with high magnetization. The observed flocculation was attributed to the aggregation of unstable and small particles through surface charge neutralization, electrostatic patching, and/or bridging after addition of flocculants. The results showed that the nanocomposites could be a potential green flocculant for recovering microalgae with low cost and high efficiency.
Nowadays, people face many different dangers, such as stress, unsafety food, and environmental pollution, but not everyone suffers. Meanwhile, free radicals are the biggest threat for humans because they lead to over 80 different diseases composed of aging. Free radicals can only be eliminated or minimized with antioxidant foods or antioxidants. The chapter on the functional-antioxidant food presents the antioxidant functional food concept, the classification, the structure, and the extraction process of antioxidant ingredients. Various antioxidant substances such as protein (collagen), polysaccharides (fucoidans, alginates, glucosamines, inulins, laminarins, ulvans, and pectins), and secondary metabolites (polyphenols (phlorotannins, lignins, polyphenols), alkaloids, and flavonoids) also present. The production technology, the mechanism, the opportunity, and the challenge of antioxidants functional food also present in the current chapter. The current chapter also gives the production process of functional-antioxidant food composed of the capsule, the tablet, tube, the pills, the powder, and the effervescent tablet.
Antibody-drug conjugates (ADCs) are consisted of the combination of highly specific monoclonal antibodies (mAbs) with conventional cytotoxic agents to particular cancer types. The use of mAbs that are specific to tumor cell-surface proteins allows highly selective accumulation of cytotoxic agents as ADCs at the tumor tissue, that is not achievable with conventional cytotoxic agents alone. Designing of effective ADCs for cancer treatment requires identification of an appropriate target, a mAb against the target, potent cytotoxic agents and conjugation of the mAb to cytotoxic agents. Until now, three ADCs including Gemtuzumab ozogamicin, Brentuximab and trastuzumab emtansine have received an FDA approval so far. These three ADCs have shown improved efficacy and safety data compared with standard chemotherapy for the treatment of patients of acute myeloid leukemia, advanced lymphoma and breast cancer, respectively. Moreover, several promising ADCs are now in the latter-phase of clinical testing. Thus, with special focusing on these new anti-cancer drugs, this review briefly describes the principles of ADCs including their structure and mechanism of action, and summarizes their clinical performance in breast cancer. Citation: Nguyen Phuong Loan, Duong Hong Quan, 2017. Antibody-drug conjugates: Principles and clinical results in breast cancer treatment. Tap chi Sinh hoc, 39(4): 489-493. DOI: 10.15625/0866-7160/v39n4.9327.*Corresponding author: quanvspt@gmail.comReceived 15 March 2017, accepted 12 December 2017
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