The cyclodehydration of Bohlmann-Rahtz aminodienones is catalysed by iodine in ethanol at room temperature to give 2,3,6-trisubstituted pyridines in excellent yield, with total regiocontrol and without the need for chromatographic purification.
Pyridine derivatives R 0380Iodine-Catalyzed Bohlmann-Rahtz Cyclodehydration Reactions. -Iodine in ethanol is used as catalyst to give 2,3,6-trisubstituted pyridines (II) under mild conditions in excellent yields. -(BAGLEY*, M. C.; GLOVER, C.; CHEVIS, D.; Synlett 2005, 4, 649-651; Sch. Chem., Cardiff Univ., Cardiff CF1 3TB, UK; Eng.) -C. Oppel 32-140
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