Author contributions: All a�thors contrib�ted eq�ally to the conception and design of this article, drafting the man�script and revising it critically for important intellectual content�� ��nally�� t�e �� ��nally�� t�e ��nally�� t�e version to be p�blished was approved by the three a�thors.

In a Spanish population from Madrid, mutations of the NOD2/CARD15 gene were a marker of susceptibility to Crohn disease and were associated with ileal disease. Carriers of the G908R mutation showed a stricturing disease behavior, history of appendectomy, and surgical interventions over the course of the disease.

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